PEG-MGF (Pegylated Mechano Growth) is one of my personal favorite peptides. In fact, it's the best variant of Growth on the market today when it comes to site growth. Specifically, it's a splice that's responsible for both damaged muscle recovery and satellite cell growth.
For starters, think about muscle growth like putting together a large hormonal puzzle. The picture gets clearer once we understand that the puzzle is made up of pieces like DHT, MGF. Some of these hormones are expelled by the liver as a response to damaged muscle tissue. For example,hormone helps release growth help. One of the variants of growth help is MGF, better known as mechano growth peptides. In the past, you had to depend on your body to produce MGF naturally, but not anymore. Now that scientists have been able to isolate and reproduce these peptide chains, bodybuilders and athletes can recover faster and increase hypertrophy like never before.
MGF has been used by bodybuilders and athletes for a few years already. After resistance exercise,IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. (1) It differs from "regular" IGF-1 mainly due to it's C-Terminal sequenc.
MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-Ireceptor domain which ithen in turn ncreases protein synthesis turnover, and therefore can if used correctly improve muscle mass over time.
The average dose is 1000 mcg per 24 hours; the frequency is 2-3 times per week. The drug is injected subcutaneously 1-2 hours before training to imitate physiologic secretion. The cycle duration is 5-6 weeks.
It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage. The C-terminal peptide of the mechano factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is econded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule.
MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.
It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.
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