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Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.As a result, it is approximately three times more potent than IGF-1,and possesses a significantly longer half-life of about 20-30 hours (relative to IGF-1's half-life of about 12-15 hours).
The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.
IGF-1Lr3 Fuction
- enlarged amino acid transporting cells
- increased protein production
- reduced protein degradation
- amplified glucose transporting
- augmented RNA combination
IGF-1Lr3
IGF-1Lr3 has a half-life of about 20-30 hours and is much more potent than base IGF-1LR3. Since its half-life is about a day, the IGF-1Lr3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren't necessary, as IGF-1Lr3 will cycle the body binding to all muscle cells for about a day.
IG-F1 vs. HG-H
Why IGF-1LR3 and not GH? Growth hormone actually is a precursor to IGF-1LR3 Growth hormone does not directly cause muscle growth, but indirectly causes muscle growth by signaling the release of IGF-1LR3.Human Growth Hormone (HG-H) can be very expensive, and to see muscle growth it needs to be paired with insulin or other anabolic steroids. This makes IGF-1LR3 variants like LR3 and DES, which can be used as a standalone drug, a much more viable option for bodybuilder looking to see solid recovery of damaged tissue and muscle growth.
Another concern with methyl 1-test (and methylated steroids in general) is hepatotoxicity. Other substances that are toxic to the liver (such as alcohol) should be avoided to avoid placing extra stress on the liver. Milk thistle, alpha lipoic acid, and N-acetyl-cysteine are commonly recommended to help protect the liver.
When taking methyl 1-test, it is best to start out with at least a week at a dose of 5-10 mg to see how you react. Many find a lower dose to be just as effective as a higher one, but with less side effects. Most seem to find their ideal dose to be in the 10-30 mg range. Cycle length should be kept short, in the range of 1-4 weeks.
How to Storage?
- It is recommended to store metribolone at the room temperature below 30 degrees C.
- Keep the drug away from direct sunlight, heat and moisture.
Peptides |
HGH Fragment 176-191 2mg/vial |
PT-141 10mg/vial |
Melanotan-I 10mg/vial |
Melanotan-II 10mg/vial |
Sermorelin 2mg/vial |
Hexarelin 2mg/vial |
Tesamorelin 2mg/vial |
MGF 5mg/vial |
PEG MGF 2mg/vial |
Ipamorelin 2mg/vial |
CJC-1295 with DAC 2mg/vial |
CJC-1295 without DAC 2mg/vial |
TB500 2mg/vial 5mg/vial |
Triptorelin 2mg/vial |
GHRP-2 5mg/vial |
GHRP-6 5mg/vial |
Oxytocin 2mg/vial |
Gonadorelin 2mg/vial |
DSIP 2mg/vial |
Selank 5mg/vial |
Follistatin 344 1mg/vial |
Follistatin 315 1mg/vial |
Epitalon 10mg/vial |
Pentadecapeptide Bpc 157 2mg/vial |
Fax: 86-537